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Zammit is president and CEO of Clinilabs, director of the Sleep Disorders Institute, and clinical associate professor at the Columbia University College of Physicians and Surgeons in New York City. Zammit is a consultant to Boehringer-Ingelheim, sanofi-aventis, Sepracor, and Takeda; receives research support from Forest, Glaxo Smith Kline, Pfizer, sanofi-aventis, Sepracor, Takeda Pharmaceuticals North America, Transcept, and Wyeth; and receives honoraria from Takeda. Possible trazodone potentiation of fluoxetine: a case series. Acknowledgments: The author would like to thank Ms. The presence of insomnia symptoms in individuals with a current episode of major depressve disprder (MDD) has been shown to approach 80% to 90%. Several longitudinal studies have examined the incidence of psychiatric disorders over periods ranging from 1–40 years following the initial diagnosis of insomnia. Pohl R, Bridges M, Rainey JM Jr, Boudoulas H, Yeragani VK. In every study completed to date, insomnia has been found to be a significant risk factor for the subsequent onset of depression, with a greater incidence of affective disorder found in people with insomnia. Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease. Almost 80% of the survey respondents indicated that they would prescribe trazodone to address selective serotonin reuptake inhibitor (SSRI)-induced insomnia.

The type of sleep disturbance produced by depression pharmacotherapy varies based on the compound’s mechanism of action and the dosage employed. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M.

Effects may include decrements in rapid eye movement (REM) sleep, a lengthening of the time to sleep onset, and an increase in nocturnal arousals (Table 1). Ventricular arrhythmias possibly aggravated by trazodone.

This article reviews the effectiveness and safety of several treatment options for comorbid depression and insomnia.

This article examines the evidence supporting the efficacy and safety of mood stabilizers in the treatment of comorbid and primary insomnia. Complete heart block following a single dose of trazodone.

Psychiatric disorders and chronic insomnia are often comorbid with each other.

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